Integrity review halted

Submitting a manuscript for peer review--integrity, integrity, integrity.

Publication of a flawed manuscript has significant consequences for the progress of science. When this proves to be intentional, science is brought into disrepute and this puts even more pressure on the shrinking resources that society is prepared to invest in research. All scientific journals, including the Journal of Neurochemistry, have witnessed a marked increase in the number of correction...

Salmeterol (Serevent) asthma trial halted early.

Sperm Aneuploidy and Dna Integrity: a Review

Male factors leading to infertility account for at least half of all cases of infertility worldwide. The purpose of this review is to highlight the importance of sperm DNA integrity. A systematic literature search was performed up to January 2015 in order to determine the impact of sperm DNA integrity and of the techniques used to determine it. Only articles presenting sperm aneuploidy together...

Maintaining the integrity of peer review.

FOR MOST JOURNALS, peer review remains the cornerstone of deciding which manuscripts to publish. At its best, peer review does much more than simply decide between accept and reject. Thoughtful, unbiased analyses by scientific peers often reveal issues not considered by the authors themselves, attention to which during revision almost always improves the quality of the paper. Sometimes, valuabl...

Recent research highlights importance of trials halted 10 years ago.

NSABP's B-14 trial was originally launched to evaluate whether women with lymph node – negative, estrogen receptor – positive breast cancer benefi t from tamoxifen treatment. Researchers also designed the trial to test the duration of tamoxifen therapy necessary to get the most benefi t from the drug. In late 1995, an analysis of the study data revealed that the benefi ts of 5 years of tamoxife...